Applied Medical Informatics

The informatics group develops methods to quantitatively analyze clinical and preclinical image data in the scope of interdisciplinary research. One aim is to automate certain image segmentation or analysis steps, or at least minimize the required user input, to achieve a high level of user independence and therefore reproducibility.
Dr. rer. medic. F. Gremse

Selected publications

  1. Gremse F, Stärk M, Ehling J, Lammers T, Menzel JR, Kiessling F. Imalytics Preclinical: Interactive Analysis of Biomedical Volume Data. Theranostics. 2016;6(3)
  2. Gremse F, Höfter A, Razik L, Kiessling F, Naumann U. GPU-accelerated adjoint algorithmic differentiation. Comput. Phys. Commun. 2016;200
  3. Gremse F, Doleschel D, Zafarnia Z, Babler A, Jahnen-Dechent W, Lammers T, Lederle W, Kiessling F. Hybrid µCT-FMT imaging and image analysis. JOVE. 2015;100
  4. Gremse F, Höfter A, Schwen LO, Kiessling F, Naumann U. GPU-Accelerated Sparse Matrix-Matrix Multiplication by Iterative Row Merging. SIAM J Sci Comput. 2015;37(1):C54–71.

  1. Gremse F, Theek B, Kunjachan S, Lederle W, Pardo A, Barth S, Lammers T, Naumann U, and Kiessling F. Absorption reconstruction improves biodistribution assessment of fluorescent nanoprobes using hybrid fluorescence-mediated tomography. Theranostics. 2014;4(10):960‑71.
  2. Gremse F, Krone O, Thamm M, Kiessling F, Tolba RH, Rieger S, and Gremse C. Performance of lead-free versus lead-based hunting ammunition in ballistic soap. PLoS ONE. 2014;9(7):e102015.
  3. Al Rawashdeh W, Arns S, Gremse F, Ehling J, Knüchel-Clarke R, Kray S, Spöler F, Kiessling F, and Lederle W. Optical tomography of MMP activity allows a sensitive noninvasive characterization of the invasiveness and angiogenesis of SCC xenografts. Neoplasia. 2014;16(3):235‑46, 246.e1.
  4. Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RTA, Heyll K, Noels H, Hristov M, Wang S, Kiessling F, Olson EN, and Weber C. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 2014;20(4):368‑76.
  5. Ehling J, Theek B, Gremse F, Baetke S, Möckel D, Maynard J, Ricketts S, Grüll H, Neeman M, Knuechel R, Lederle W, Kiessling F, and Lammers T. Micro-CT imaging of tumor angiogenesis: quantitative measures describing micromorphology and vascularization. Am J Pathol. 2014;184(2):431‑41.
  6. Kunjachan S, Gremse F, Theek B, Koczera P, Pola R, Pechar M, Etrych T, Ulbrich K, Storm G, Kiessling F, and Lammers T. Noninvasive optical imaging of nanomedicine biodistribution. ACS Nano. 2013;7(1):252‑62.

Group members

Kerstin Küpper

Kerstin (M.Sc. Math) is working on numerical modelling in the context of diffuse optical tomography.

Stefanie Rosenhain

Stefanie (M.Sc. Biochemistry 2015 FSU Jena) is working on establishing molecular markers (fluorescent-labelled probes) for the detection of inflammatory bowel diseases via FMT-CT analysis in vivo.


S. Rosenhain

Grace Gyamfuah Yamoah

Grace (M.Tech. Software Engineering) develops software tools for data curation in the context of multimodal clinical and preclinical imaging studies.

Simin Zuo

Simin (M.Sc. Biomedical Engineering 2015 Tsinghua University, China) is working on quantitative parameter analysis using hybrid fluorescence-mediated tomography, in the context of angiogenesis, inflammation and drug delivery.


S. Zuo