Applied Medical Informatics

The applied informatics group develops software tools in the scope of interdisciplinary research. We implement and evaluate quantitative reconstruction methods for multimodal fluorescence tomography and evaluate these in applied studies. Furthermore, we develop software for interactive and automated analysis of clinical and preclinical image data with the aim to minimize the required user input and to achieve a high level of user independence and reproducibility.
Dr. rer. medic. F. Gremse

Selected publications

  1. Al Rawashdeh W, Zuo S, Melle A, Appold L, Koletnik S, Tsvetkova Y, Beztsinna N, Pich A, Lammers T, Kiessling F, and Gremse F. Noninvasive Assessment of Elimination and Retention using CT-FMT and Kinetic Whole-body Modeling. Theranostics. 2017;7(6):1499‑1510.
  2. Rosenhain S, Al Rawashdeh W, Kiessling F, and Gremse F. Sensitivity and accuracy of hybrid fluorescence-mediated tomography in deep tissue regions. J Biophotonics. 2017;10(9):1208‑1216.
  3. Gremse F, Höfter A, Razik L, Kiessling F, and Naumann U. GPU-Accelerated Adjoint Algorithmic Differentiation. Comput Phys Commun. 2016;200:300‑311.
  4. Gremse F, Stärk M, Ehling J, Menzel JR, Lammers T, and Kiessling F. Imalytics Preclinical: Interactive Analysis of Biomedical Volume Data. Theranostics. 2016;6(3):328‑41.
  5. Gremse F, Doleschel D, Zafarnia S, Babler A, Jahnen-Dechent W, Lammers T, Lederle W, and Kiessling F. Hybrid µCT-FMT imaging and image analysis. J Vis Exp. 2015(100):e52770.
  6. Gremse F, Theek B, Kunjachan S, Lederle W, Pardo A, Barth S, Lammers T, Naumann U, and Kiessling F. Absorption reconstruction improves biodistribution assessment of fluorescent nanoprobes using hybrid fluorescence-mediated tomography. Theranostics. 2014;4(10):960‑71.

Group members

Stefanie Rosenhain

Stefanie (M.Sc. Biochemistry 2015 FSU Jena) is working on establishing molecular markers (fluorescent-labelled probes) for the detection of inflammatory bowel diseases via FMT-CT analysis in vivo.


S. Rosenhain

Grace Gyamfuah Yamoah

Grace (M.Tech. Software Engineering) develops software tools for data curation in the context of multimodal clinical and preclinical imaging studies.


GG. Yamoah

Simin Zuo

Simin (M.Sc. Biomedical Engineering 2015 Tsinghua University, China) is working on quantitative parameter analysis using hybrid fluorescence-mediated tomography, in the context of angiogenesis, inflammation and drug delivery.


S. Zuo

Zuzanna Magnuska

Zuzanna works on artificial intelligence-based solutions for automated segmentation, analysis and processing of multimodal medical images (pre-clinical and clinical data). Moreover, the methods (i.e. feature extraction and selection) will be used to interpret the content of medical images. The correlation between generated information and biological parameters will be investigated to assess redundancy and complementarity.


Z. Magnuska

Alexey Sorokin

Alexey Sorokin (Diploma in Physics from Lomonosov MSU) works on accurate and efficient modelling of diffuse optical tomography data to better understand and improve fluorescence tomography reconstruction methods.


A. Sorokin