Ultrasound is one of the most frequently used imaging modalities in clinical routine. It is real-time, safe, transportable and offers excellent spatial resolution and tissue contrast. However, for a long period of time its clinical applications did not exploit its full potential. With the introduction of microbubbles as contrast agents, ultrasound enables a detailed and quantitative characterization of tissue microvascularisation, and recently, the first molecularly targeted microbubbles have entered clinical application. In addition, there is clear evidence that contrast-enhanced ultrasound has significant potential to improve drug delivery by using mechanical forces from oscillating microbubbles to open biological barriers. Furthermore, microbubbles can also be loaded with drugs and act as drug carriers releasing their content only at the target site after local ultrasound exposure. Ultrasound imaging has been one of the main research topics of Professor Fabian Kiessling for over 10 years. With the new “Diagnostic and Therapeutic Ultrasound” group in ExMI, it is our intention to intensify our efforts in ultrasound research and to focus our translational research on
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![]() Univ.-Prof. Dr. med. Fabian Kiessling ![]() ![]() |
Selected publicationsResearch Papers
Reviews / Perspectives
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Group members |
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Anne RixAnne (B.Sc. in Molecular Biology, JGU Mainz) works as a lab technician and her main focus is functional and molecular ultrasound methods for assessing tumor angiogenesis and anti-angiogenic therapy effects. In addition, she is working on immunohistochemistry, microscopy and on different diagnostic and therapeutic in vivo and ex vivo experiments. |
![]() A. Rix |
Milita DarguzyteMilita (M.Sc. Biomedical Engineering, FH Aachen, 2017) is working on a project “Theranostic Riboflavin-Targeted Drug Delivery”. The project comprises synthetic work on the theranostic drug carriers, their in vitro and in vivo characterization as well as the evaluation of their therapeutic potential in tumor bearing mice. |
![]() M. Darguzyte |
Jasmin BaierJasmin (M.Sc. in Biology, Goethe University Frankfurt, 2016) is working on the influence of molecular imaging on study results and animal welfare. |
![]() J. Baier |
Gurbet KöseGurbet (M.Sc., University of Bristol) is part of the research training group “Tumor-Targeted Drug Delivery”. She works on the project “Sonoporation to improve drug delivery to breast cancer”. The project comprises work on microbubbles in combination with sonoporation to improve drug delivery system accumulation and efficacy. |
![]() K. Gurbet |
Lisa Marie BartmannLisa (MD Student) is working on Riboflavin-Uptake by endothelial, epithelial and tumor cells. |
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Elena RamaElena (M.Sc. in Pharmaceutical Chemistry and Technology, University of Urbino, Italy 2018) is a PhD student involved in a project focused on the development and monitoring of biohybrid tissue-engineered vascular grafts both in vitro and in animal models, via using several hybrid imaging techniques as PET-MRI. |
![]() E. Rama |
Jinwei QiJinwei Qi (Master of Imaging Medicine and Nuclear Medicine, Dalian Medical University, 2014) works on ultrasound-mediated gene delivery via lipoplex coupled to PBCA-based polymeric microbubbles. |
![]() J. Qi |
Junlin ChenJunlin Chen (Master of Biomedical Engineering and Ultrasound, Chongqing Medical University, China 2019) is a PhD student, who is involved in a project regarding establishment and evaluation of ultrasound mediated RNA delivery. |
![]() J. Chen |
Zuzanna Anna MagnuskaZuzanna (M.Sc. Biomedical Engineering 2018 RWTH Aachen, Germany and Ing. Biomedical Engineering 2018 CTU Prague, Czech Republic) works on artificial intelligence-based solutions for automated segmentation, analysis and processing of multimodal medical images (pre-clinical and clinical data). |
![]() Z. Magnuska |
Helen HeinrichsHelen Heinrichs (M.Sc. in Global Health, Maastricht University, 2019) is involved in a project focusing on artificial intelligence in diagnosis as part of precision medicine. Her research revolves around identifying social, ethical and professional challenges that might hinder the uptake of AI in the clinical routine work. |
![]() H. Heinrichs |
Sarah SchravenSarah Schraven(M. Sc. Drug Development, 2020, KU Leuven, Belgium) is a PhD student working on in vivo imaging of the gut-liver axis using fluorescence molecular tomography, computed tomography and magnetic resonance imaging. |
![]() S. Schraven |