The group “Mechanisms of Tumor Progression and Metastasis” aims at elucidating the mechanisms of tumor growth and progression, with a special focus on the impact of the tumor micro-environment and the longitudinal in-vivo characterization by non-invasive imaging. Besides tumor staging and improved diagnosis, further attempts are directed to monitor therapy effects, including the evaluation of novel therapeutics. In-vivo imaging is complemented by histological and functional in-vitro analyses in order to validate the data and to identify new potential markers and targets. |
![]() Dr. rer. nat. W. Lederle |
Selected publicationsResearch Papers
Reviews / Perspectives
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Group members |
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Susanne KoletnikSusanne (B.Sc. in Molecular Biology, JGU Mainz) works as a lab technician and is involved in many different projects, focusing on the in vivo characterization of tumor initiation and progression, as well as the assessment of therapeutic effects, using different imaging modalities. Furthermore she contributes to cell culture, histological analysis and diagnostic and therapeutic in vitro experiments. |
![]() S. Koletnik |
Dr. Dennis DoleschelDennis (Dr. rer. medic. Dipl.-Biol.) uses novel imaging methods and contrast agents for molecular investigations of physiological and pathophysiological processes. In addition, he analyzes the effects of novel therapeutics on cancer progression using non-invasive imaging techniques. |
![]() D. Doleschel |
Anna MrugallaAnna (M.Sc. in Biochemistry, Hannover Medical School, 2015) works in a systems medicine project on chronic liver diseases (LiSyM). She is doing multimodal and multiparametric analysis of acute and chronic liver injury focusing on alterations in cell composition, extracellular matrix deposition, perfusion and tissue architecture of the liver. |
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Eva FiegleEva (MD student) investigates the role of inflammation and angiogenesis in tumor progression and metastasis. |
![]() E. Fiegle |
Maximilian SneltingMaximilian (MD student) investigates tumor inflammation and angiogenesis by non-invasive imaging. |
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Flurin Müller-DiesingFlurin (MD student) investigates tumor angiogenesis and inflammation by non-invasive imaging. |
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Matthias MisiewiczMatthias (MD student, RWTH Aachen University) investigates the endothelial expression of different angiogenesis receptors in human breast cancer. The aim of his work is to verify the clinical relevance of aberrant protein expression patterns, particularly with regard to establishing new molecular imaging modalities in cancer diagnostics.. |
![]() M. Misiewicz |
Sara ZafarniaSara (M.Sc. in Biotechnology, RWTH Aachen University, 2012) works in a BMBF funded systems biology project on liver regeneration (Virtual Liver Network). Her main focus is to investigate and characterize macrophage activation during liver regeneration by noninvasive fluorescence tomography. In addition, she is investigating liver vascularization and growth during liver regeneration and after alterations in the hepatic blood flow. |
![]() S. Zafarnia |