Polymeric Nanomedicines

The group “Polymeric Nanomedicines” aims to design and synthesize amphiphilic block copolymers which are used to construct nanomedicines with high tunability and functionality. One of the main activities of the group is to prepare nanoparticles composed of polymers with finely tuned chemical structures synthesized via advanced polymerization techniques, which can achieve efficient drug delivery to pathological sites. Efforts are made to develop versatile platform technologies in order to deliver compounds of various physicochemical nature and pharmacological activities. An important focus of the group is to develop nanomedicines which are functionalized with imaging agents, which enable in vivo visualization and contribute to personalized and precision nanomedicines.
Dr. Yang Shi

Selected publications

  1. Shi Y, Cardoso R, Nostrum CF, and Hennink WE. Anthracene Functionalized Thermosensitive and UV-Crosslinkable Polymeric Micelles. Polymer Chemistry. 2015; 6:2048-53
  2. Shi Y, Nostrum CF, and Hennink WE. Interfacially Hydrazone Crosslinked Thermosensitive Polymeric Micelles Showed De-Crosslinking and Accelerated Paclitaxel Release at Acidic pH. ACS Biomaterials Science & Engineering. 2015; 1: 393-404

  1. Shi Y, Kunjachan S, Wu Z, Gremse F, Moeckel D, van Zandvoort M, Kiessling F, Storm G, van Nostrum CF, Hennink WE, and Lammers T. Fluorophore labeling of core-crosslinked polymeric micelles for multimodal in vivo and ex vivo optical imaging. Nanomedicine. 2015;10(7):1111‑25.
  2. Shi Y, van der Meel R, Theek B, Oude Blenke E, Pieters EHE, Fens MHAM, Ehling J, Schiffelers RM, Storm G, van Nostrum CF, Lammers T, and Hennink WE. Complete Regression of Xenograft Tumors upon Targeted Delivery of Paclitaxel via Π-Π Stacking Stabilized Polymeric Micelles. ACS Nano. 2015;9(4):3740‑52.
  3. Shi Y, Elkhabaz A, Yengej FAY, van den Dikkenberg J, Hennink WE, and van Nostrum CF. π-π Stacking induced enhanced molecular solubilization, singlet oxygen production, and retention of a photosensitizer loaded in thermosensitive polymeric micelles. Adv Healthc Mater. 2014;3(12):2023‑31.

Group members

Zaheer Ahmed

Zaheer (M.Sc. Life Science, Hanyang University, South Korea, 2015) works on the development of targeted nanoparticles for the treatment of cancers. The underlying purpose of his DAAD fellowship is to harness the potential of inorganic nanoparticles such as nanoceria and to employ them to improve the efficacy and reduce the toxicity of anticancer therapy.

Z. Ahmed

Xiangyang Bai

Xiangyang (M.Sc. in Material Science and Engineering, 2015) conducted research on inorganic nanoparticles as novel antibiotics at The Technical Institute of Physics and Chemistry, Chinese Academy of Sciences. Currently he is performing his PhD research on the development of polymeric nanotheranostics for the treatment of cancer, via a grant funded by the China Scholarship Council (CSC).

X. Bai

Mengjiao Liu

Mengjiao (M.Sc. in Pharmaceutics, Sichuan Agricultural University, China 2015) obtained a stipend from the China Scholarship Council (CSC) to join the Nanomedicine and Theranostics group. The primary aim of her work is to develop multifunctional microbubbles to enhance drug delivery across the blood-brain barrier (BBB) and to improve the treatment of brain tumors.

M. Liu