Open Positions at PMI/ExMI (Prof. V. Schulz)
Three PhD positions are available at the moment, to work on I) the development and preclinical evaluation of liposomal nanomedicines; II) the development of a 3D-printed tumor angiogenesis model; and III) functional and molecular imaging of inflammation-associated angiogenesis. Please contact: T. Lammers for more details.
We always welcome medical, undergraduate and graduate students from RWTH Aachen and other national and international universities to carry out research projects (e.g. internship, thesis project, etc…) at our institute. Please contact the Groups Leaders for more information.
M.Sc thesis project: Establishment of a protocol for multiplex immunofluorescent histology using cryostat slices
The accumulation of nanomedicine formulations at pathological sites often depends on the enhanced permeability and retention effect (EPR). EPR is known to be very heterogeneous, both in animal models and in patients, and even within a single patient and tumor.
Our aim is to better understand the (patho-) physiological parameters contributing to EPR. For this reason it is important to quantify the histological parameters, which lead to a higher or lower accumulation of nanomedicines. The expression of certain tumor markers needs to be correlated to the amount of nanomedicines, which we want to do using multiplex immunofluorescent histology.
Further information regarding the method which will be established during this master project, can be gained here: PerkinElmer
The candidate will be trained in tumor cell culture and histological analyses, like 2-photon and immunofluorescence histology. I further studies an in vivo tumor model will be used. Methods established at our department for in vivo tumor models include functional and molecular ultrasound, photoacoustic and µCT.
Skills / Experience Requirements
– high motivation in research
– interest in imaging in biology / medicine
– pursuing a degree in biology, biotechnology or a related field
– laboratory and cell culture experience would be advantageous